brain repair after stroke

Here is a very interesting grand rounds at UCSD about brain repair after stroke


principles of brain repair from grand rounds

1. brain repair is time sensitive - stroke physiology is a sequence of cellular events, have to time treatments accordingly (sequence growth factors, or if give NMDA blockers early kill recovery)
2. brain repair is experience dependent - need exposure to the lost function, task specific rehabilitation + repitition that leads to increase in behavioral recovery
3. have to optimize patient selection type, many therapies are $$, and there are many variables that modify outcome (age, handedness, genetics, medications, timing of events...)
4.value of domain specific endpoints - less global endpoints may be needed to understand repair issues because global recovery may be too broad to measure whats working